DNA methylation is an important epigenetic regulator that plays crucial roles in various biological processes.Recent developments in experimental approaches and dramatic expansion of sequencing capacities have imposed new challenges in the analysis of large-scale, cross-species DNA methylation data.Hence, user-friendly toolkits with high usability
Abstract Objectives The objective of our study was to test the hypothesis that in utero repair of surgically created spina bifida in a sheep model using cryopreserved human umbilical cord (HUC) patch improves neurological outcome.Methods Spina bifida with myelotomy was surgically created in timed pregnant ewes at gestational day (GD) 75.The fetuses
The study of soil enzyme activities under different land use is of importance for exploration of the soil quality evolution and its evaluation during the Slicing revegetation at karst area in Nanchuan, Chongqing, China.Seven kinds of land use were chosen as subject, aiming at revealing the changes in soil enzyme activities through experimental and
Experimental evidence is increasingly being used to reassess the quality and accuracy of genome annotation.Proteomics data used for this purpose, called proteogenomics, can alleviate many of the problematic areas of genome annotation, e.g.short protein validation and start site assignment.We performed a proteogenomic analysis of 46 genomes spanning